Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine in Mexico.
Rev Panam Salud Publica
; 33(6): 414-21, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23939366
ABSTRACT
OBJECTIVE:
To assess the safety and immune responses induced by a 13-valent pneumococcal conjugate vaccine (PCV13) after immunization of infants in Mexico.METHODS:
PCV13 was given with other routine childhood vaccinations to 225 infants in Mexico at ages 2, 4, 6, and 12 months.RESULTS:
The proportions of subjects achieving immunoglobulin G (IgG) concentrations ≥0.35 µg/mL after the infant series and toddler dose were ≥93.1% and ≥96.7%, respectively, for all 13 serotypes. The serotype-specific pneumococcal IgG geometric mean concentrations after the infant series and toddler dose ranged from 1.18 to 9.13 µg/mL and from 1.62 to 15.41 µg/mL, respectively. The most common local reaction and systemic event after each dose were tenderness and irritability, respectively. Most fever was mild; no fever >40.0°C (i.e., severe) was reported. One subject withdrew because of Kawasaki disease 5 days after the first dose of vaccines, but this condition was not considered related to PCV13.CONCLUSIONS:
Overall, PCV13 administered with routine pediatric vaccines was immunogenic and safe in healthy infants in Mexico.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas Neumococicas
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Infant
/
Male
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Rev Panam Salud Publica
Asunto de la revista:
SAUDE PUBLICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
México