Association between interleukin 1ß and interleukin 10 concentrations: a cross-sectional study in young adolescents in Taiwan.
BMC Pediatr
; 13: 123, 2013 Aug 14.
Article
en En
| MEDLINE
| ID: mdl-23941335
ABSTRACT
BACKGROUND:
In adults, low circulating interleukin 10 (IL10) has been associated with obesity and type 2 diabetes. However, studies investigating IL10 in overweight and obese children have yielded conflicting results. The aim of this study was to investigate factors associated with serum IL10 concentration in young Chinese adolescents.METHODS:
Young adolescents (n=325) ages 13.33±1.10 years were recruited into the cross-sectional study from 2010 to 2011. Parameters of obesity, individual components of MetS, iron status and serum IL10 were evaluated.RESULTS:
Compared with their normal weight counterparts, overweight adolescents had lower serum IL10 but higher TNFα, nitric oxide (NO) and IL1ß concentrations (all p<0.05). Obese adolescents had increased IL1ß but decreased hepcidin concentration compared with normal weight (p<0.01 and p<0.05; respectively). A strong inverse relationship (p<0.0001) was found between IL10 and pro-inflammatory cytokines (TNFα and IL1ß). Multivariate linear regression analysis showed serum IL1ß was significantly correlated with IL10 (ß=-0.156, p<0.0001). When overweight and obese adolescents were assessed separately from normal weight, only IL1ß was inversely associated with serum IL10 (ß=-0.231, p=0.0009). The association between IL10 and IL1ß was weaker in adolescents with normal weight (ß=-0.157, p=0.0002), after adjusting for gender, TNFα, IFNγ and NO.CONCLUSIONS:
Our study confirmed that low IL10 concentration is associated with overweight and obesity in young adolescents. We also demonstrated for the first time that pro-inflammatory cytokine IL1ß is independently associated with IL10. A decline in IL10 concentration in overweight and obese adolescents may further contribute to the IL1ß-mediated inflammatory environment associated with obesity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Índice de Masa Corporal
/
Interleucina-10
/
Sobrepeso
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Interleucina-1beta
/
Obesidad
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
BMC Pediatr
Asunto de la revista:
PEDIATRIA
Año:
2013
Tipo del documento:
Article