High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
Oncoimmunology
; 2(7): e24679, 2013 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-24073364
ABSTRACT
The accumulation of immunosuppressive cells and exhausted effector T cells highlight an important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients. These cells significantly hamper the efficacy immunotherapies and facilitate HCC progression. We have recently demonstrated that the multipronged depletion of immunosuppressive cells potentially restores effector T-cell function in HCC.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
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En
Revista:
Oncoimmunology
Año:
2013
Tipo del documento:
Article