Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactionsElectronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and intermediates. Details for the biological evaluation. Further details for the modeling. Table of combustion analysis data. See DOI: 10.1039/c3md00161jClick here for additional data file.

Blackburn, Tim J; Ahmed, Shafiq; Coxon, Christopher R; Liu, Junfeng; Lu, Xiaohong; Golding, Bernard T; Griffin, Roger J; Hutton, Claire; Newell, David R; Ojo, Stephen; Watson, Anna F; Zaytzev, Andrey; Zhao, Yan; Lunec, John; Hardcastle, Ian R

Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactionsElectronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and intermediates. Details for the biological evaluation. Further details for the modeling. Table of combustion analysis data. See DOI: 10.1039/c3md00161jClick here for additional data file.

Blackburn, Tim J; Ahmed, Shafiq; Coxon, Christopher R; Liu, Junfeng; Lu, Xiaohong; Golding, Bernard T; Griffin, Roger J; Hutton, Claire; Newell, David R; Ojo, Stephen; Watson, Anna F; Zaytzev, Andrey; Zhao, Yan; Lunec, John; Hardcastle, Ian R.

Afiliación

Blackburn TJ; Newcastle Cancer Centre , Northern Institute for Cancer Research and School of Chemistry , Newcastle University , Bedson Building , Newcastle , NE1 7RU , UK . Email: Ian.Hardcastle@ncl.ac.uk ; ; Tel: +44 (0)191 222 6645.

Medchemcomm ; 4(9): 1297-1304, 2013 Sep 21.

Article en En | MEDLINE | ID: mdl-24078862

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Medchemcomm Año: 2013 Tipo del documento: Article Pais de publicación: Reino Unido

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