Total synthesis of epothilone D: the nerol/macroaldolization approach.
J Org Chem
; 78(21): 10588-95, 2013 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-24079664
ABSTRACT
A highly convergent and stereocontrolled synthesis of epothilone D (4) is reported. Key features are a cheap and Z-selective synthesis of the northern half based on nerol and acetoacetate and chromium(II)-mediated Reformatsky reactions as a powerful tool for chemoselective asymmetric carbon-carbon bond formations, including an unusual stereospecific macroaldolization.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Macrólidos
/
Epotilonas
/
Aldehídos
Idioma:
En
Revista:
J Org Chem
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania