The immediate response of jejunal mucosa to small bowel heterotopic allotransplatation in rats.
Tissue Cell
; 46(1): 21-6, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24079856
ABSTRACT
The course of histopathological alterations within jejunal graft architecture during the initial adaptation phase in the host body was investigated. Graft tissues were compared to the intestinal tissues of the recipients. This study demonstrates (1) renewal of intestinal epithelial lining in the graft biopsies during initial hours after transplantation is more likely caused by migration and extension of remaining epithelial cells than by their increased mitotic division. (2) Distinct decrease in histopathological injury was observed in transplanted grafts after 6h, but the morphometrical parameters, particularly villus height and wall thickness, remained altered. (3) Significant decrease in apoptotic cell death in the epithelial lining within 6h of graft recirculation was accompanied by no effect on apoptosis levels of the cells in lamina propria connective tissue. (4) Although the apoptosis level in the connective tissue cells was not modulated in the grafts within the first hour after transplantation, caspase-3 dependent apoptosis was decreased significantly.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Tejidos
/
Apoptosis
/
Mucosa Intestinal
/
Yeyuno
Límite:
Animals
Idioma:
En
Revista:
Tissue Cell
Año:
2014
Tipo del documento:
Article
País de afiliación:
Eslovaquia