Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins.
Bioorg Med Chem
; 21(22): 6920-8, 2013 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-24103429
This paper reports the synthesis of a series of evodiamine derivatives. We assayed the ability to inhibit cell growth on three human tumour cell lines (H460, MCF-7 and HepG2) and we evaluated the capacity to interfere with the catalytic activity of topoisomerase I both by the relaxation assay and the occurrence of the cleavable complex. Moreover, whose effect on sirtuins 1, 2 and 3 was investigated. Finally, molecular docking analyses were performed in an attempt to rationalize the biological results.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinazolinas
/
ADN-Topoisomerasas de Tipo I
/
Sirtuinas
/
Inhibidores de Topoisomerasa I
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Reino Unido