[Comparison of the results of ethacizin pharmacodynamics and pharmacokinetics in a single intravenous administration]. / Sopostavlenie rezul'tatov farmakodinamiki i farmakokinetiki étatsizina pri razovom vnutrivennom vvedenii.
Kardiologiia
; 25(4): 32-5, 1985 Apr.
Article
en Ru
| MEDLINE
| ID: mdl-2410654
ABSTRACT
A single intravenous injection of 30-50 mg ethacizin produces a favourable antiarrhythmic effect in 80-85% of patients with ventricular disorders of cardiac rhythm. The drug's action already begins "on the needle", reaches its peak within 3-5 minutes and lasts for 1-2 hours. A two-compartment model adequately represents ethacizin pharmacokinetics. The average ethacizin half-distribution and half-elimination periods are 4.7 and 154.4 minutes, respectively, and its clearance rate is 0.99 1/min. Therapeutic plasma concentration of the drug varies between 30-50 and 300-400 ng/ml.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenotiazinas
/
Moricizina
/
Antiarrítmicos
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Kardiologiia
Año:
1985
Tipo del documento:
Article
Pais de publicación:
FEDERAÇÃO RUSSA
/
RU
/
RUSIA
/
RUSSIA