[Comparison of the results of ethacizin pharmacodynamics and pharmacokinetics in a single intravenous administration]. / Sopostavlenie rezul'tatov farmakodinamiki i farmakokinetiki étatsizina pri razovom vnutrivennom vvedenii.

ABSTRACT

A single intravenous injection of 30-50 mg ethacizin produces a favourable antiarrhythmic effect in 80-85% of patients with ventricular disorders of cardiac rhythm. The drug's action already begins "on the needle", reaches its peak within 3-5 minutes and lasts for 1-2 hours. A two-compartment model adequately represents ethacizin pharmacokinetics. The average ethacizin half-distribution and half-elimination periods are 4.7 and 154.4 minutes, respectively, and its clearance rate is 0.99 1/min. Therapeutic plasma concentration of the drug varies between 30-50 and 300-400 ng/ml.