Depleted TGF-ß1 levels in end stage renal disease patients from North India.
Gene
; 534(2): 440-3, 2014 Jan 25.
Article
en En
| MEDLINE
| ID: mdl-24113078
ABSTRACT
End stage renal disease is a clinical state that extends from chronic renal failure and is marked by an irreversible loss of renal function. TGF-ß1 mediated renal fibrosis is a common pathology implicated in this form of kidney disease. In this study circulating protein and mRNA levels of TGF-ß1 cytokine were investigated among ESRD patients and respective controls from North India. Physician diagnosed 192 ESRD patients, on hemodialysis, and 130 normal controls participated in the present study. TGF-ß1 circulating levels were measured by ELISA and its expression was quantified using competitive-PCR. Mean TGF-ß1 protein levels were 2.7-fold lower in ESRD patients as compared to normal controls (p<0.001). Additionally, TGF-ß1 mRNA transcripts of this cytokine were also significantly lower in the diseased population compared to controls (p<0.001). These results imply that TGF-ß1 has not played its anticipated pro-fibrotic role and anti-inflammatory function in the studied population.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor de Crecimiento Transformador beta1
/
Fallo Renal Crónico
Límite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Gene
Año:
2014
Tipo del documento:
Article