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The sulphonylurea receptor may be an ATP-sensitive potassium channel.
Lancet ; 2(8453): 474-5, 1985 Aug 31.
Article en En | MEDLINE | ID: mdl-2412077
The stimulation of insulin secretion from the beta cells of the islets of Langerhans appears to be mediated by a decrease in the cell-membrane potassium-ion permeability. Tolbutamide reduced K+ movement through an ATP-sensitive K+ channel in patches of plasma membrane from an insulin-producing cell line when applied to the external surface of the membrane. The effect occurred at concentrations which exist in the serum of patients treated with tolbutamide and which stimulate insulin secretion from islets of Langerhans in vitro. Glibenclamide had a similar effect but, in keeping with its greater therapeutic potency, at concentrations one hundred times lower. These findings suggest that an ATP-sensitive K+ channel or a protein closely associated with it may be the receptor through which sulphonylureas act to stimulate insulin secretion in vitro.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Sulfonilurea / Adenosina Trifosfato / Islotes Pancreáticos / Canales Iónicos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Lancet Año: 1985 Tipo del documento: Article Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Sulfonilurea / Adenosina Trifosfato / Islotes Pancreáticos / Canales Iónicos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Lancet Año: 1985 Tipo del documento: Article Pais de publicación: Reino Unido