Anxiolytic activity of dipeptide GB-115 after oral administration.
Bull Exp Biol Med
; 155(2): 200-3, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-24130989
The anxiolytic effects of GB-115, a retroanalogue of cholecystokinin-4, administered orally to outbred and inbred animals with different level of emotionality, were studied in the open field test and elevated plus-maze test. The anxiolytic effect of talanax was observed in outbred mice (0.1-0.5 mg/kg) and in inbred BALB/c mice (0.1 and 5.0 mg/kg) in the open field test. GB-115 increased the time of entries into open arms in outbred rats (0.5-0.7 mg/kg) and in BALB/c mice (0.1 mg/kg). These data confirmed the dependence of GB-115 effect on the phenotype of emotional stress response and demonstrated a shift of anxiolytic doses of the preparation from 0.006-0.100 mg/kg in intraperitoneal administration to 0.1-5.0 mg/kg in oral treatment.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Psicológico
/
Tetragastrina
/
Ansiolíticos
/
Colecistoquinina
/
Dipéptidos
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2013
Tipo del documento:
Article
País de afiliación:
Rusia
Pais de publicación:
Estados Unidos