[Phenotypic screens or one stone to kill two birds: discover the target and its pharmacological regulator]. / Les criblages phénotypiques ou comment faire d'une pierre deux coups: découvrir la cible et la molécule pharmacologique capable de la réguler.
Med Sci (Paris)
; 29(10): 897-905, 2013 Oct.
Article
en Fr
| MEDLINE
| ID: mdl-24148129
ABSTRACT
Phenotypic screens, in which chemical libraries are assayed on cells with the aim to isolate compounds that interfere with a given cell function, are a risky but powerful strategy to discover, in the same approach, new therapeutic targets and the compounds able to regulate them. With a strong experience of nearly 10 years in the field, we present the advantages of such an approach, the possible troubles and technical solutions. We also present in this paper a french network which has been recently built and that gather all the competencies needed for screening approaches.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Evaluación Preclínica de Medicamentos
/
Bibliotecas de Moléculas Pequeñas
/
Terapia Molecular Dirigida
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
Fr
Revista:
Med Sci (Paris)
Asunto de la revista:
MEDICINA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
FR
/
FRANCE
/
FRANCIA
/
FRANÇA