Incubation of saccharin craving and within-session changes in responding for a cue previously associated with saccharin.
Appetite
; 72: 114-22, 2014 Jan.
Article
en En
| MEDLINE
| ID: mdl-24161592
ABSTRACT
Time-dependent increases in cue-induced sucrose seeking after forced abstinence have been described in rats with a history of sucrose self-administration, suggesting sucrose craving "incubates". In the present study, we examined whether the incubation of craving generalizes to the artificial sweetener, saccharin. Thirty-one male Long-Evans rats lever pressed for 0.3% saccharin solution 1h/day for 10 days. On either Day 1 or 30 of forced abstinence, rats responded for 1h for presentation of a tone+light cue previously presented with every saccharin delivery during self-administration training. Rats responded more during this cue-reactivity test session following 30 vs. 1 day of forced abstinence ("incubation of craving"). This result is the first demonstration of the "incubation of saccharin craving" and suggests that a post-ingestive caloric consequence of self-administration is not a necessary condition for the development of incubation of sucrose craving. We also examined the time course (within-session decreases) of active-lever responding during the 1-h cue-reactivity test session. Rats in the Day 30 group responded more than rats in the Day 1 group from the beginning of the test session. In addition, within-session decreases in responding were shallower in slope in the Day 30 than the Day 1 group. These results indicate that "incubation of saccharin craving" enhances the persistence of seeking behavior.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sacarina
/
Edulcorantes
/
Ingestión de Energía
/
Conducta Adictiva
/
Condicionamiento Operante
/
Extinción Psicológica
/
Preferencias Alimentarias
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Appetite
Año:
2014
Tipo del documento:
Article