Signaling mechanisms of non-conventional axon guidance cues: the Shh, BMP and Wnt morphogens.
Curr Opin Neurobiol
; 23(6): 965-73, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-24183376
ABSTRACT
During nervous system development, axons, led by the growth cone, must navigate to their destinations. Axon guidance cues are molecules in the extracellular environment that attract or repel axons to guide them along their correct trajectory. The non-conventional axon guidance cues include morphogens of the Hedgehog, TGF-ß/BMP, and Wnt/Wgl families. Canonical signaling by morphogens regulates transcription in the nucleus to specify cell fate. Recent studies have begun to elucidate how these morphogens can also direct growth cone turning, using signaling mechanisms that diverge from their canonical signaling pathways. Furthermore, in addition to directly guiding axons, some non-conventional guidance cues such as Sonic hedgehog also modulate the response of axons to other guidance cues, adding another level of regulation to axon guidance.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Axones
/
Transducción de Señal
/
Proteínas Morfogenéticas Óseas
/
Proteínas Wnt
/
Proteínas Hedgehog
/
Neurogénesis
Tipo de estudio:
Guideline
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Neurobiol
Asunto de la revista:
BIOLOGIA
/
NEUROLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Canadá