Real time and accelerated stability studies of Tetanus toxoid manufactured in public sector facilities of Pakistan.
Pak J Pharm Sci
; 26(6): 1271-8, 2013 11.
Article
en En
| MEDLINE
| ID: mdl-24191338
ABSTRACT
Tetanus is an acute illness represented by comprehensive increased inflexibility and spastic spasms of skeletal muscles. The poor quality tetanus toxoid vaccine can raise the prevalence of neonatal tetanus. WHO has taken numerous steps to assist national regulatory authorities and vaccine manufacturers to ensure its quality and efficacy. It has formulated international principles for stability evaluation of each vaccine, which are available in the form of recommendations and guidelines. The aim of present study was to ensure the stability of tetanus vaccines produced by National Institute of Health, Islamabad, Pakistan by employing standardized methods to ensure constancy of tetanus toxoid at elevated temperature, if during storage/transportation cold chain may not be maintained in hot weather. A total of three batches filled during full-scale production were tested. All Stability studies determination were performed on final products stored at 2-8°C and elevated temperatures in conformance with the ICH Guideline of Stability Testing of Biological Products. These studies gave comparison between real time shelf-life stability and accelerated stability studies. The findings indicate long-term thermo stability and prove that this tetanus vaccine can remain efficient under setting of routine use when suggested measures for storage and handling are followed in true spirit.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Toxoide Tetánico
Tipo de estudio:
Risk_factors_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Pak J Pharm Sci
Asunto de la revista:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Pakistán
Pais de publicación:
PAKISTAN
/
PAQUISTÃO
/
PK