Marked elevation of transaminases and pancreatic enzymes in severe malnourished male with eating disorder.
Clin Ter
; 164(5): e387-91, 2013.
Article
en En
| MEDLINE
| ID: mdl-24217841
ABSTRACT
We report a case of a 45 year old Caucasian malnourished male with an history of eating disorder who developed severe liver and pancreatic damage and multiorgan disfunction. At admission to our department, his body mass index (BMI) was 11.1. Biochemical evaluation showed elevated serum levels of transaminases (AST= 2291 U/L, ALT= 1792 U/L), amylase (3620 U/L), lipase (4102 U/L), CPK= 1370 U/L, LDH= 2082 U/L. No other cause of acute liver and pancreatic damage was evidenced. Haematological disorders (anemia, thrombocytopenia, leukopenia) found on admission seem related to bone marrow hypoplasia and to gelatinous marrow transformation described in severe state of malnutrition. Although a moderate increase in liver and pancreatic enzymes are a common finding in malnourished patients, only a small number of reports describes severe liver injury and multiorgan dysfunction. After a few days of treatment (hydration and nutritional support) a marked decrease of serum transaminases, lipase, amylase, CPK, LDH occurred, despite a transient increase in these levels secondary to refeeding syndrome. The association of chronic malnutrition and a decrease in systemic perfusion may be responsible for multiorgan dysfunction. In our patient the high levels of transaminases and pancreatic enzymes were the most important biochemical abnormalities normalized after refeeding.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aspartato Aminotransferasas
/
Anorexia
/
Desnutrición
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Alanina Transaminasa
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Alfa-Amilasas Pancreáticas
/
Lipasa
Tipo de estudio:
Etiology_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Ter
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia