Entecavir-associated myopathy: a case report and literature review.
Muscle Nerve
; 49(4): 610-4, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24218312
ABSTRACT
INTRODUCTION:
Entecavir, a nucleoside analog (NA), is effective for treatment of chronic hepatitis B virus (HBV) infection.METHODS:
We report the case of a patient we encountered with entecavir-associated myopathy. We also performed a literature review of myopathies associated with nucleoside analogs.RESULTS:
A 44-year-old man presented with a 3-month history of myalgia and progressive weakness. He had HBV infection and had received entecavir antiviral treatment for 5 years. Laboratory tests showed that serum creatine kinase levels were significantly elevated. Muscle histopathology showed abundant T-lymphocyte infiltration of muscle fibers, and HBV surface antigen and HBV core antigen were not present in muscle fibers. Entecavir-associated myopathy was subsequently diagnosed. The patient's symptoms eventually resolved, and serum CK levels decreased rapidly after he stopped receiving entecavir treatments.CONCLUSIONS:
Patients who receive NA therapy should be closely monitored for myopathic side effects. Muscle Nerve 49610-614, 2014.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Guanina
/
Enfermedades Musculares
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Muscle Nerve
Año:
2014
Tipo del documento:
Article
País de afiliación:
China