Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy.
J Virol
; 88(3): 1830-3, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24257620
ABSTRACT
Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine spongiform encephalopathy (BSE) prions, which have the ability to overcome species barriers. Tg(CerPrP)1536(+/-) mice challenged with red deer-adapted BSE resulted in 90% to 100% attack rates, and BSE from cattle failed to transmit, indicating agent adaptation in the deer.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Priones
/
Ciervos
/
Encefalopatía Espongiforme Bovina
/
Enfermedad Debilitante Crónica
/
Modelos Animales de Enfermedad
/
Ratones
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido