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Association analysis of ERBB2 amplicon genetic polymorphisms and STARD3 expression with risk of gastric cancer in the Chinese population.
Qiu, Yue; Zhang, Zuo-Yang; Du, Wei-Dong; Ye, Lei; Xu, Song; Zuo, Xian-Bo; Zhou, Fu-Sheng; Chen, Gang; Ma, Xue-Ling; Schneider, Marion E; Xia, Hong-Zhen; Zhou, Yuan; Wu, Ji-Feng; Yuan-Hong, Xu; Zhang, Xue-Jun.
Afiliación
  • Qiu Y; Department of Biology, School of Life Sciences, Anhui Medical University, Hefei 230032, China.
  • Zhang ZY; Department of Pathology, Anhui Medical University, Hefei 230032, China.
  • Du WD; Department of Biology, School of Life Sciences, Anhui Medical University, Hefei 230032, China; State Key Laboratory & Incubation Base of Dermatology of Ministry of National Science and Technology, Anhui Medical University, Hefei 230032, China; Sektion Experimentelle Anaesthesiologie, Universitae
  • Ye L; Department of Biology, School of Life Sciences, Anhui Medical University, Hefei 230032, China.
  • Xu S; Department of Biology, School of Life Sciences, Anhui Medical University, Hefei 230032, China.
  • Zuo XB; State Key Laboratory & Incubation Base of Dermatology of Ministry of National Science and Technology, Anhui Medical University, Hefei 230032, China.
  • Zhou FS; State Key Laboratory & Incubation Base of Dermatology of Ministry of National Science and Technology, Anhui Medical University, Hefei 230032, China.
  • Chen G; State Key Laboratory & Incubation Base of Dermatology of Ministry of National Science and Technology, Anhui Medical University, Hefei 230032, China.
  • Ma XL; MVZ, ACURA Kliniken, Baden-Baden 76530, Germany.
  • Schneider ME; Sektion Experimentelle Anaesthesiologie, Universitaetsklinikum Ulm, Ulm 89081, Germany.
  • Xia HZ; Department of Biology, School of Life Sciences, Anhui Medical University, Hefei 230032, China.
  • Zhou Y; Department of Biology, School of Life Sciences, Anhui Medical University, Hefei 230032, China.
  • Wu JF; Department of Pathology, Anhui Medical University, Hefei 230032, China.
  • Yuan-Hong X; Clinical Laboratory, the First Affiliated Hospital, Anhui Medical University, Hefei 230032, China.
  • Zhang XJ; State Key Laboratory & Incubation Base of Dermatology of Ministry of National Science and Technology, Anhui Medical University, Hefei 230032, China.
Gene ; 535(2): 225-32, 2014 Feb 10.
Article en En | MEDLINE | ID: mdl-24291029
The purpose of this study was to investigate whether risk of gastric cancer (GC) was associated with single nucleotide polymorphisms (SNPs) in a gene cluster on the chromosome 17q12-q21 (ERBB2 amplicon) in the Chinese Han population. We detected twenty-six SNPs in this gene cluster containing steroidogenic acute regulatory-related lipid transfer domain containing 3 (STARD3), protein phosphatase 1 regulatory subunit 1B (PPP1R1B/DARPP32), titin-cap (TCAP), per1-like domain containing 1(PERLD1/CAB2), human epidermal growth factor receptor-2 (ERBB2/HER2), zinc-finger protein subfamily 1A 3 (ZNFN1A3/IKZF3) and DNA topoisomerase 2-alpha (TOP2A) genes in 311 patients with GC and in 425 controls by Sequenom. We found no associations between genetic variations and GC risk. However, haplotype analysis implied that the haplotype CCCT of STARD3 (rs9972882, rs881844, rs11869286 and rs1877031) conferred a protective effect on the susceptibility to GC (P=0.043, odds ratio [OR]=0.805, 95% confidence intervals [95% CI]=0.643-0.992). The STARD3 rs1877031 TC genotype endued histogenesis of gastric mucinous adenocarcinoma and signet-ring cell carcinoma (P=0.021, OR=2.882, 95% CI=1.173-7.084). We examined the expression of STARD3 in 243 tumor tissues out of the 311 GC patients and 20 adjacent normal gastric tissues using immumohistochemical (IHC) analysis and tissue microarrays (TMA). The expression of STARD3 was observed in the gastric parietal cells and in gastric tumor tissues and significantly correlated with gender (P=0.004), alcohol drinking (P<0.001), tumor location (P=0.007), histological type (P=0.005) and differentiation (P=0.023) in GC. We concluded that the combined effect of haplotype CCCT of STARD3 might affect GC susceptibility. STARD3 expression might be related to the tumorigenesis of GC in the Chinese population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Neoplasias Gástricas / Proteínas Portadoras / Receptor ErbB-2 / Pueblo Asiatico / Estudios de Asociación Genética / Proteínas de la Membrana Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Gene Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Neoplasias Gástricas / Proteínas Portadoras / Receptor ErbB-2 / Pueblo Asiatico / Estudios de Asociación Genética / Proteínas de la Membrana Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Gene Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos