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Species-specific inflammatory responses as a primary component for the development of glomerular lesions in mice and monkeys following chronic administration of a second-generation antisense oligonucleotide.
Frazier, Kendall S; Sobry, Cécile; Derr, Victoria; Adams, Mike J; Besten, Cathaline Den; De Kimpe, Sjef; Francis, Ian; Gales, Tracy L; Haworth, Richard; Maguire, Shaun R; Mirabile, Rosanna C; Mullins, David; Palate, Bernard; Doorten, Yolanda Ponstein-Simarro; Ridings, James E; Scicchitano, Marshall S; Silvano, Jérémy; Woodfine, Jennie.
Afiliación
  • Frazier KS; Department of Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA kendall.s.frazier@gsk.com.
  • Sobry C; CiToxLab, Evreux, France.
  • Derr V; Pathology, Microbiology and Immunology, University of California-Davis, California, USA.
  • Adams MJ; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom.
  • Besten CD; Prosensa Therapeutics, Leiden, The Netherlands.
  • De Kimpe S; Prosensa Therapeutics, Leiden, The Netherlands.
  • Francis I; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom.
  • Gales TL; Department of Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA.
  • Haworth R; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom.
  • Maguire SR; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom.
  • Mirabile RC; Department of Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA.
  • Mullins D; Department of Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA.
  • Palate B; CiToxLab, Evreux, France.
  • Doorten YP; Prosensa Therapeutics, Leiden, The Netherlands.
  • Ridings JE; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom.
  • Scicchitano MS; Department of Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA.
  • Silvano J; CiToxLab, Evreux, France.
  • Woodfine J; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom.
Toxicol Pathol ; 42(5): 923-35, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24292388
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligonucleótidos Antisentido / Inflamación / Enfermedades Renales / Glomérulos Renales Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Toxicol Pathol Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligonucleótidos Antisentido / Inflamación / Enfermedades Renales / Glomérulos Renales Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Toxicol Pathol Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos