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B-cell modulation of dendritic-cell function: signals from the far side.
Eur J Immunol ; 44(1): 23-32, 2014 Jan.
Article en En | MEDLINE | ID: mdl-24307285
ABSTRACT
An appropriate immune response against a specific pathogen requires finely orchestrated interactions between the various cell populations within the immune system. At the same time, immunological tolerance to self must be maintained. DCs play an essential role in achieving these dual requisites. They coordinate adaptive immunity by integrating signals directly emanating from both infectious agents and cells of the immune system. Many such signals, especially those from innate cells and T cells, have been extensively characterized. In contrast, little is known about how B cells modulate function of DCs. B cells produce a variety of cytokines, including IL-10 and IL-6, which are known to influence DC function. In addition, Igs constitute the major secretory products of terminally differentiated B cells (plasma cells). DCs express various types of receptors for binding Ig, such as Fc receptors and C-type lectin receptors. In accordance, Igs can regulate DC function depending on the receptors engaged. Here, we review the emerging immunomodulatory role of cytokines and Ig secreted by B cells. We discuss the evidence for how these B-cell-derived factors may shape the adaptive immune response by directly acting on DCs.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Dendríticas / Linfocitos B / Comunicación Celular Límite: Animals / Humans Idioma: En Revista: Eur J Immunol Año: 2014 Tipo del documento: Article
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Dendríticas / Linfocitos B / Comunicación Celular Límite: Animals / Humans Idioma: En Revista: Eur J Immunol Año: 2014 Tipo del documento: Article