Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal women.
Am J Reprod Immunol
; 71(2): 95-108, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24313954
ABSTRACT
PROBLEM:
The goal of this study was to investigate the phenotype and functional responsiveness of CD4(+) and CD8(+) T-cells in the upper reproductive tract of healthy premenopausal women. The lower reproductive tract is frequently studied as a site of sexually transmitted infections; however, the upper reproductive tract may also be a portal of entry and dissemination for pathogens, including HIV-1. METHOD OF STUDY Endometrial biopsy, endocervical curettage, cytobrush, and blood were collected during mid-luteal phase from 23 healthy women. T-cells were isolated and analyzed by flow cytometry.RESULTS:
As compared with their counterparts in blood, endometrial and endocervical T-cells had enhanced CCR5 expression, and were enriched for activated, effector memory cells. Endometrial T-cells were more responsive to polyclonal stimuli, producing a broad range of cytokines and chemokines.CONCLUSION:
These findings underscore the responsiveness of endometrial T-cells to stimulation, and reveal their activated phenotype. These findings also suggest susceptibility of the upper reproductive tract to HIV-1 infection.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T CD4-Positivos
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Cuello del Útero
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Subgrupos de Linfocitos T
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Linfocitos T CD8-positivos
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Endometrio
Límite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Am J Reprod Immunol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos