Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium.

Peart, Jason N; Pepe, Salvatore; Reichelt, Melissa E; Beckett, Nikkie; See Hoe, Louise; Ozberk, Victoria; Niesman, Ingrid R; Patel, Hemal H; Headrick, John P

Peart, Jason N; Pepe, Salvatore; Reichelt, Melissa E; Beckett, Nikkie; See Hoe, Louise; Ozberk, Victoria; Niesman, Ingrid R; Patel, Hemal H; Headrick, John P.

Afiliación

Peart JN; Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, Australia.
Pepe S; Heart Research, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.
Reichelt ME; Department of Physiology, University of Melbourne, Parkville, VIC, Australia.
Beckett N; Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, Australia.
See Hoe L; Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, Australia.
Ozberk V; Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, Australia.
Niesman IR; VA San Diego Healthcare System, San Diego, USA.
Patel HH; VA San Diego Healthcare System, San Diego, USA; Department of Anesthesiology, University of California San Diego, USA.
Headrick JP; Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Southport, Australia. Electronic address: j.headrick@griffith.edu.au.

Exp Gerontol ; 50: 72-81, 2014 Feb.

Article en En | MEDLINE | ID: mdl-24316036

Asunto(s)

Envejecimiento/fisiología; Daño por Reperfusión Miocárdica/fisiopatología; Anciano; Animales; Membrana Celular/metabolismo; Citoprotección/fisiología; Humanos; Precondicionamiento Isquémico Miocárdico; Masculino; Ratones; Ratones Endogámicos C57BL; Persona de Mediana Edad; Mitocondrias Cardíacas/metabolismo; Daño por Reperfusión Miocárdica/metabolismo; Miocardio/metabolismo; Técnicas de Cultivo de Órganos; Proteína Quinasa C/metabolismo; Receptores Acoplados a Proteínas G/agonistas; Receptores Acoplados a Proteínas G/metabolismo; Transducción de Señal/fisiología; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

AKT; Aging; CAV-3; Cardioprotection; Caveolae; Cyt c; ERK1/2; G-protein coupled receptor kinase 2; G-protein coupled receptors; GRK2; GSK3ß; Hormesis; Ischemia mitochondria; MAPK/ERK kinase; MEK; PI3K; PKC; PKG; PLC; PLD; Protein kinase; RTK; Ras homolog family member A; RhoA; Stress-resistance; caveolin-3; cytochrome c; eNOS; endothelial nitric oxide synthase; extracellular signal-regulated kinase 1/2; glycogen synthase kinase 3ß; mK(ATP); mPTP; mTOR; mechanistic target of rapamycin; mitochondrial ATP-gated K(+) channels; mitochondrial permeability transition pore; p38; p38-mitogen activated protein kinase; p70 ribosomal protein S6 kinase; p70s6K; phosphoinositide 3-kinase; phospholipase C; phospholipase D; protein kinase B; protein kinase G; protein kinase c; receptor tyrosine kinase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Daño por Reperfusión Miocárdica Límite: Aged / Animals / Humans / Male / Middle aged Idioma: En Revista: Exp Gerontol Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido

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