Improved differentiation between MS and vascular brain lesions using FLAIR* at 7 Tesla.
Eur Radiol
; 24(4): 841-9, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24317461
ABSTRACT
OBJECTIVES:
To investigate whether a new magnetic resonance image (MRI) technique called T2*-weighted fluid attenuation inversion recovery (FLAIR*) can differentiate between multiple sclerosis (MS) and vascular brain lesions, at 7 Tesla (T).METHODS:
We examined 16 MS patients and 16 age-matched patients with (risk factors for) vascular disease. 3D-FLAIR and T2*-weighted images were combined into FLAIR* images. Lesion type and intensity, perivascular orientation and presence of a hypointense rim were analysed.RESULTS:
In total, 433 cerebral lesions were detected in MS patients versus 86 lesions in vascular patients. Lesions in MS patients were significantly more often orientated in a perivascular manner 74 % vs. 47 % (P < 0.001). Ten MS lesions (2.3 %) were surrounded by a hypointense rim on FLAIR*, and 24 MS lesions (5.5 %) were hypointense on T2*. No lesions in vascular patients showed any rim or hypointensity. Specificity of differentiating MS from vascular lesions on 7-T FLAIR* increased when the presence of a central vessel was taken into account (from 63 % to 88 %), most obviously for deep white matter lesions (from 69 % to 94 %). High sensitivity remained (81 %).CONCLUSION:
7-T FLAIR* improves differentiation between MS and vascular lesions based on lesion location, perivascular orientation and presence of hypointense (rims around) lesions. KEY POINTS ⢠A new MRI technique T2*-weighted fluid attenuation inversion recovery (FLAIR*) was investigated. ⢠FLAIR* at 7-T MRI combines FLAIR and T2* images into a single image. ⢠FLAIR* at 7 T does not require enhancement with contrast agents. â¢High-resolution 7-T FLAIR* improves differentiation between MS and vascular brain lesions. ⢠FLAIR* revealed a central vessel more frequently in MS than vascular lesions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Procesamiento de Imagen Asistido por Computador
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Encéfalo
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Imagen por Resonancia Magnética
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Esclerosis Múltiple
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur Radiol
Asunto de la revista:
RADIOLOGIA
Año:
2014
Tipo del documento:
Article