c-Kit expression in somatosensory nuclei of lower medulla oblongata.
Rom J Morphol Embryol
; 54(3 Suppl): 721-4, 2013.
Article
en En
| MEDLINE
| ID: mdl-24322018
ABSTRACT
Protein kinase signal-transduction pathways play critical roles in regulating nociception. The c-kit receptor contributes to pain regulation in the spinal cord and is present on both peripheral and central terminals. Expression of c-kit was demonstrated in human trigeminal and spinal ganglia. However, the brainstem expression of c-kit was overlooked. We aimed to evaluate it by immunohistochemistry, on eight samples of human lower medulla oblongata. We used two clones of CD117/c-kit antibodies, from different manufacturers, and neurofilament antibodies. Positive expression of CD117/c-kit was found within the spinal trigeminal nucleus, the gracilis, cuneate, and lateral cuneate nuclei, and within the olivary complex. CD117/c-kit positive interstitial networks of these nuclei were positively labeled with neurofilaments. CD117/c-kit labeled the olivary neurons, but not the magnocellular neurons of the trigeminal, gracilis and cuneate nuclei. c-kit interstitial systems of brainstem could play so an important role for the functional status along the somatosensory neural circuits.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bulbo Raquídeo
/
Proteínas Proto-Oncogénicas c-kit
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Rom J Morphol Embryol
Asunto de la revista:
ANATOMIA
/
EMBRIOLOGIA
Año:
2013
Tipo del documento:
Article