Activated chlorine dioxide solution can be used as a biocompatible antiseptic wound irrigant.
Adv Skin Wound Care
; 27(1): 13-9, 2014 Jan.
Article
en En
| MEDLINE
| ID: mdl-24343388
ABSTRACT
OBJECTIVE:
The purpose of this study was to compare cosmesis at 3 to 4 months and infection in simple lacerations irrigated with normal saline (NS) versus activated chlorine dioxide (CD).DESIGN:
This was a prospective, randomized trial of a convenience sample of patients. This study was approved by the institutional review board and Food and Drug Administration as a physician-sponsored trial (FDA investigational new drug no. 68762).SETTING:
The study was conducted in a large urban, academic emergency department. PATIENTS Patients aged 18 to 100 with simple, uncomplicated lacerations requiring repair that were less than 8 hours old were enrolled.INTERVENTIONS:
Patients were randomized to receive either NS or CD wound irrigation. MAIN OUTCOMEMEASURES:
Demographics, infection, and cosmesis were analyzed and assessed. Cosmetic outcome was assessed at 3 to 4 months using a visual analog scale (VAS), wound evaluation score (WES), patient VAS (VASPt), and digital imaging VAS by 2 plastic surgeons (VASPlast). MAINRESULTS:
One hundred ninety-three patients were enrolled. Data analysis was available for 175 cases (86 NS and 89 CD). Wound infection follow-up was obtained in 74.9% of the patients. The 3- to 4-month cosmesis follow-up was 37.7% for VAS/WES, 40.0% for VASPt, and 37.7% for VASPlast. There were no significant differences in demographics, key wound characteristics, infection, adverse reactions, and cosmesis.CONCLUSION:
The authors report the use of a novel antimicrobial irrigation solution. Chlorine dioxide appears to be a safe biologically acceptable antiseptic wound irrigant that does not appear to interfere with cosmetic outcomes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Óxidos
/
Infección de Heridas
/
Compuestos de Cloro
/
Laceraciones
/
Antiinfecciosos Locales
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Adv Skin Wound Care
Asunto de la revista:
ENFERMAGEM
Año:
2014
Tipo del documento:
Article