Coexistence of HIV-1 variants with dipeptidic insertion in the reverse transcriptase gene.
Rev Saude Publica
; 47(4): 821-3, 2013 Aug.
Article
en En, Pt
| MEDLINE
| ID: mdl-24346670
ABSTRACT
The aim of this communication was to describe the detection of the coexistence of HIV-1 variant with dipeptide insertion between codons 69 and 70 of reverse transcriptase. These variants were isolated from a 16-year-old male patient, undergoing treatment in the city of Marilia, SP, Southeastern Brazil. After confirmation of treatment failure, resistance to antiretroviral drugs testing was performed and two variants with the insertions of the aminoacids Ser-Gly/Ser-Ala at codon 69 of reverse transcriptase were detected, besides the T69S mutation. These insertions have low prevalence, have not been reported in situations of coexistence in Brazil and are related to multidrug resistance, which makes this epidemiological finding relevant.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
VIH-1
/
Inhibidores de la Transcriptasa Inversa
/
Fármacos Anti-VIH
/
Transcriptasa Inversa del VIH
Tipo de estudio:
Risk_factors_studies
Límite:
Adolescent
/
Humans
/
Male
Idioma:
En
/
Pt
Revista:
Rev Saude Publica
Año:
2013
Tipo del documento:
Article
País de afiliación:
Brasil