Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort.
Ann Rheum Dis
; 74(4): 689-93, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-24351517
ABSTRACT
OBJECTIVE:
To estimate the prevalence of spondyloarthritis (SpA) in reference to HLA-B27 in the French population.METHODS:
In 1989, 20â 625 employees of the French national gas and electricity company aged 35-50â years were enrolled in the GAZEL cohort. In 2010, 18 757 still active participants were screened by a questionnaire validated for the detection of SpA. Responders with available DNA were retained for further studies. Pelvic radiograph and HLA-B27 typing were performed in all the self-reported cases of SpA or psoriatic arthritis. Self-reported diagnosis was verified by a qualified rheumatologist. HLA-B27 determination was also performed in subjects without any SpA feature.RESULTS:
The target population consisted of 6556 responders with available DNA. Their malefemale ratio was 3.6 and their mean age was 65.5±3.3â years. A diagnosis of SpA was confirmed in 32 of the 72 self-reported cases, 75% of them being HLA-B27 positive. Estimated SpA prevalence adjusted for sex was 0.43% (95% CI 0.26% to 0.70%). HLA-B27 positivity rate in 2466 healthy controls was 6.9% (95% CI 5.9% to 7.9%). The relative risk of SpA in HLA-B27 positive individuals was 39 (95% CI 17 to 86).CONCLUSIONS:
We estimated the prevalence of SpA in the French population in 2010 to 0.43%. With an estimated prevalence of 75.0% in SpA and 6.9% in healthy controls, HLA-B27 increased the disease risk 39-fold, as compared with HLA-B27 negative subjects.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígeno HLA-B27
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Espondiloartritis
Tipo de estudio:
Etiology_studies
/
Incidence_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Ann Rheum Dis
Año:
2015
Tipo del documento:
Article
País de afiliación:
Francia