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Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation.
Williams, Jesse W; Tjota, Melissa Y; Clay, Bryan S; Vander Lugt, Bryan; Bandukwala, Hozefa S; Hrusch, Cara L; Decker, Donna C; Blaine, Kelly M; Fixsen, Bethany R; Singh, Harinder; Sciammas, Roger; Sperling, Anne I.
Afiliación
  • Williams JW; Committee on Molecular Pathogenesis and Molecular Medicine, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA.
  • Tjota MY; 1] Committee on Immunology, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA [2] Medical Scientist Training Program, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA.
  • Clay BS; Committee on Immunology, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA.
  • Vander Lugt B; Department of Discovery Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080 USA.
  • Bandukwala HS; Committee on Immunology, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA.
  • Hrusch CL; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA.
  • Decker DC; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA.
  • Blaine KM; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA.
  • Fixsen BR; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA.
  • Singh H; Department of Discovery Immunology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080 USA.
  • Sciammas R; Department of Surgery, University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637 USA.
  • Sperling AI; 1] Committee on Molecular Pathogenesis and Molecular Medicine, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA [2] Committee on Immunology, University of Chicago, 924 E. 57th Street, Chicago, Illinois 60637 USA [3] Section of Pulmonary and Critical Care Medicine, Department of
Nat Commun ; 4: 2990, 2013.
Article en En | MEDLINE | ID: mdl-24356538
Atopic asthma is an inflammatory pulmonary disease associated with Th2 adaptive immune responses triggered by innocuous antigens. While dendritic cells (DCs) are known to shape the adaptive immune response, the mechanisms by which DCs promote Th2 differentiation remain elusive. Herein we demonstrate that Th2-promoting stimuli induce DC expression of IRF4. Mice with conditional deletion of Irf4 in DCs show a dramatic defect in Th2-type lung inflammation, yet retain the ability to elicit pulmonary Th1 antiviral responses. Using loss- and gain-of-function analysis, we demonstrate that Th2 differentiation is dependent on IRF4 expression in DCs. Finally, IRF4 directly targets and activates the Il-10 and Il-33 genes in DCs. Reconstitution with exogenous IL-10 and IL-33 recovers the ability of Irf4-deficient DCs to promote Th2 differentiation. These findings reveal a regulatory module in DCs by which IRF4 modulates IL-10 and IL-33 cytokine production to specifically promote Th2 differentiation and inflammation.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Células Dendríticas / Diferenciación Celular / Células Th2 / Factores Reguladores del Interferón / Hipersensibilidad Inmediata / Pulmón Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2013 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Células Dendríticas / Diferenciación Celular / Células Th2 / Factores Reguladores del Interferón / Hipersensibilidad Inmediata / Pulmón Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2013 Tipo del documento: Article Pais de publicación: Reino Unido