Effects of secreted factors in culture medium of annulus fibrosus cells on microvascular endothelial cells: elucidating the possible pathomechanisms of matrix degradation and nerve in-growth in disc degeneration.

Moon, H J; Yurube, T; Lozito, T P; Pohl, P; Hartman, R A; Sowa, G A; Kang, J D; Vo, N V

Moon, H J; Yurube, T; Lozito, T P; Pohl, P; Hartman, R A; Sowa, G A; Kang, J D; Vo, N V.

Afiliación

Moon HJ; Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Neurosurgery, College of Medicine, Korea University, Seoul, Republic of Korea.
Yurube T; Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Lozito TP; Department of Orthopaedic Surgery, Center for Cellular and Molecular Engineering, University of Pittsburgh School of Medicine, 450 Technology Drive, Pittsburgh, PA 15219, USA.
Pohl P; Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Hartman RA; Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Sowa GA; Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Kang JD; Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: kangjd@upmc.edu.
Vo NV; Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: von@upmc.edu.

Osteoarthritis Cartilage ; 22(2): 344-54, 2014 Feb.

Article en En | MEDLINE | ID: mdl-24361793

Asunto(s)

Medios de Cultivo Condicionados/farmacología; Endotelio Vascular/metabolismo; Matriz Extracelular/patología; Degeneración del Disco Intervertebral/metabolismo; Disco Intervertebral/inervación; Adulto; Capilares/metabolismo; Supervivencia Celular; Células Cultivadas; Colágeno Tipo II/metabolismo; Células Endoteliales/efectos de los fármacos; Femenino; Humanos; Interleucina-8/biosíntesis; Disco Intervertebral/irrigación sanguínea; Degeneración del Disco Intervertebral/patología; Masculino; Metaloproteasas/metabolismo; Persona de Mediana Edad; Neovascularización Patológica/metabolismo; Factor de Crecimiento Nervioso/metabolismo; Factor de Crecimiento Derivado de Plaquetas/metabolismo; Factor A de Crecimiento Endotelial Vascular/biosíntesis

Palabras clave

Angiogenesis; Annulus fibrosus; Endothelial cells; Intervertebral disc degeneration; Metalloproteinases; Tip cells

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endotelio Vascular / Medios de Cultivo Condicionados / Matriz Extracelular / Degeneración del Disco Intervertebral / Disco Intervertebral Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Osteoarthritis Cartilage Asunto de la revista: ORTOPEDIA / REUMATOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido

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