Metabotropic glutamatergic receptors and their ligands in drug addiction.
Pharmacol Ther
; 142(3): 281-305, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24362085
ABSTRACT
Glutamatergic excitatory transmission is implicated in physiological and pathological conditions like learning, memory, neuronal plasticity and emotions, while glutamatergic abnormalities are reported in numerous neurological and psychiatric disorders, including neurodegenerative diseases, epilepsy, stroke, traumatic brain injury, depression, anxiety, schizophrenia and pain. Also, several lines of evidence have accumulated indicating a pivotal role for glutamatergic neurotransmission in mediating addictive behaviors. Among the proteins regulating glutamatergic transmission, the metabotropic glutamate receptors (mGluR) are being developed as pharmacological targets for treating many neuropsychiatric disorders, including drug addiction. In this review we describe the molecular structure of mGluRs and their distribution, physiology and pharmacology in the central nervous system, as well as their use as targets in preclinical studies of drug addiction.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Glutamato Metabotrópico
/
Trastornos Relacionados con Sustancias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Ther
Año:
2014
Tipo del documento:
Article