Prebiotic phosphate ester syntheses in a deep eutectic solvent.
J Mol Evol
; 78(2): 109-17, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24368625
ABSTRACT
We report a route to synthesize a wide range of organophosphates of biological significance in a deep eutectic solvent (21 urea and choline chloride), utilizing various orthophosphate sources. Heating an organic alcohol in the solvent along with a soluble phosphorus source yields phosphorus esters of choline as well as that of the added organic in yields between 15 to 99 %. In addition, phosphite analogs of biological phosphates and peptides were also formed by the simple mixing of reagents and heating at 60-70 °C in the deep eutectic solvent. The presented dehydration reactions are relevant to prebiotic and green chemistry in alternative solvents.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Organofosfatos
/
Solventes
/
Prebióticos
Idioma:
En
Revista:
J Mol Evol
Año:
2014
Tipo del documento:
Article