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Kelsoenethiol and dikelsoenyl ether, two unique kelsoane-type sesquiterpenes, from the Formosan soft coral Nephthea erecta.
Cheng, Shi-Yie; Shih, Neng-Lang; Hou, Kuang-Yu; Ger, Mang-Jye; Yang, Chia-Ning; Wang, Shang-Kewi; Duh, Chang-Yih.
Afiliación
  • Cheng SY; Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
  • Shih NL; Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
  • Hou KY; Department of Chemistry, Oakland University, Rochester, MI 48309, USA.
  • Ger MJ; Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
  • Yang CN; Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
  • Wang SK; Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Duh CY; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; Center of Asia-Pacific Marine Researches, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address: yihduh@mail.nsysu.edu.tw.
Bioorg Med Chem Lett ; 24(2): 473-5, 2014 Jan 15.
Article en En | MEDLINE | ID: mdl-24370010
ABSTRACT
Two new kelsoane-type sesquiterpenes, namely kelsoenethiol (1) and dikelsoenyl ether (2), were obtained from the Formosan soft coral Nephthea erecta. Their structures were elucidated through extensive spectroscopic analyses, ESI orbitrap mass and quantum chemical calculations (QCC). The cytotoxicity against A-459 (human lung carcinoma), P-388 (mouse lymphocytic leukemia), and HT-29 (human colon adenocarcinoma) cancer cell lines of 1 and 2 was evaluated in vitro. Compound 1 showed cytotoxicity against P-388 and HT-29 cells with ED50s of 1.3 and 1.8 µg/mL, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Antozoos Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article País de afiliación: Taiwán
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Antozoos Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article País de afiliación: Taiwán