Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus.

Guo, Changmei; Zhang, Zifeng; Zhang, Peng; Makita, Jun; Kawada, Hiroyoshi; Blessing, Karen; Kador, Peter F

Guo, Changmei; Zhang, Zifeng; Zhang, Peng; Makita, Jun; Kawada, Hiroyoshi; Blessing, Karen; Kador, Peter F.

Afiliación

Guo C; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Zhang Z; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Zhang P; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Makita J; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Kawada H; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Blessing K; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Kador PF; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA; Department of Ophthalmology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: pkador@unmc.edu.

Exp Eye Res ; 119: 77-87, 2014 Feb.

Article en En | MEDLINE | ID: mdl-24370601

Asunto(s)

Diabetes Mellitus Experimental/patología; Retinopatía Diabética/patología; Retina/patología; Aldehído Reductasa/biosíntesis; Animales; Western Blotting; Capilares/metabolismo; Capilares/patología; Diabetes Mellitus Experimental/metabolismo; Retinopatía Diabética/metabolismo; Progresión de la Enfermedad; Péptidos y Proteínas de Señalización Intercelular/metabolismo; Masculino; Ratones; Ratones Transgénicos; Ratas; Ratas Sprague-Dawley; Retina/metabolismo; Factores de Tiempo

Palabras clave

aldose reductase; cell signaling P-ERK1/2, P-SAPK/JNK, P-Akt; diabetic rats; diabetic retinopathy; green fluorescent proteins; growth factors VEGF, bFGF, TGF-ß; retinal vascular changes; transgenic diabetic mouse models

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retina / Diabetes Mellitus Experimental / Retinopatía Diabética Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Exp Eye Res Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

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