Immunohistochemistry evaluation of biomarker expression in non-small cell lung cancer (Pharmacogenoscan study).

Toffart, Anne-Claire; Timsit, Jean-François; Couraud, Sébastien; Merle, Patrick; Moro-Sibilot, Denis; Perol, Maurice; Mastroianni, Bénédicte; Souquet, Pierre-Jean; Girard, Nicolas; Jeannin, Gaëlle; Romand, Philippe; Chatellain, Patrick; Vesin, Aurélien; Brambilla, Christian; Brambilla, Elisabeth

Toffart, Anne-Claire; Timsit, Jean-François; Couraud, Sébastien; Merle, Patrick; Moro-Sibilot, Denis; Perol, Maurice; Mastroianni, Bénédicte; Souquet, Pierre-Jean; Girard, Nicolas; Jeannin, Gaëlle; Romand, Philippe; Chatellain, Patrick; Vesin, Aurélien; Brambilla, Christian; Brambilla, Elisabeth.

Afiliación

Toffart AC; Université Grenoble 1, INSERM, U 823, Institut A Bonniot, Université J Fourier, Rond-point de la Chantourne, 38706 La Tronche Cedex, France; Thoracic Oncology Unit, Teaching Hospital A Michallon, BP217, 38043 Grenoble Cedex 9, France. Electronic address: AToffart@chu-grenoble.fr.
Timsit JF; Université Grenoble 1, INSERM, U 823, Institut A Bonniot, Université J Fourier, Rond-point de la Chantourne, 38706 La Tronche Cedex, France; Medical Intensive Care Unit, Teaching Hospital A Michallon, BP217, 38043 Grenoble Cedex 9, France.
Couraud S; Pulmonology Department, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite Cedex, France; Lyon Sud Faculty of Medicine, Lyon 1 University, 165 chemin du Petit Revoyet, BP 12, 69921 Oullins Cedex, France.
Merle P; Respiratory Medicine, Thoracic Oncology Unit, Centre Hospitalier Universitaire G. Montpied, 58 Rue Montalembert, 63003 Clermont Ferrand Cedex 1, France; EA 7283, Université d'Auvergne, INSERM CIC 501, Bât.3C, Faculté de médecine, 63001 Clermont-Ferrand Cedex, France.
Moro-Sibilot D; Université Grenoble 1, INSERM, U 823, Institut A Bonniot, Université J Fourier, Rond-point de la Chantourne, 38706 La Tronche Cedex, France; Thoracic Oncology Unit, Teaching Hospital A Michallon, BP217, 38043 Grenoble Cedex 9, France.
Perol M; Thoracic Oncology Unit, Croix-Rousse Hospital, Hospices Civils de Lyon, 103 Grande Rue de la Croix-Rousse, 69317 Lyon Cedex 04, France.
Mastroianni B; Respiratory Medicine Service, Hôpital Louis Pradel, Hospices Civils de Lyon, 59 boulevard Pinel, 69677 Bron Cedex, France.
Souquet PJ; Pulmonology Department, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite Cedex, France; Lyon Sud Faculty of Medicine, Lyon 1 University, 165 chemin du Petit Revoyet, BP 12, 69921 Oullins Cedex, France.
Girard N; Respiratory Medicine Service, Hôpital Louis Pradel, Hospices Civils de Lyon, 59 boulevard Pinel, 69677 Bron Cedex, France; Université Claude Bernard Lyon 1, 43 boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France.
Jeannin G; Respiratory Medicine, Thoracic Oncology Unit, Centre Hospitalier Universitaire G. Montpied, 58 Rue Montalembert, 63003 Clermont Ferrand Cedex 1, France.
Romand P; Respiratory Medicine Service, Hôpitaux du Leman, 3 avenue de la Dame, BP 526, 74203 Thonon Les Bains, France.
Chatellain P; Respiratory Medicine Service, Centre Hospitalier Alpes Leman, 558 route de Findrol, BP 20 500, 74130 Contamine sur Arve, France.
Vesin A; Université Grenoble 1, INSERM, U 823, Institut A Bonniot, Université J Fourier, Rond-point de la Chantourne, 38706 La Tronche Cedex, France.
Brambilla C; Université Grenoble 1, INSERM, U 823, Institut A Bonniot, Université J Fourier, Rond-point de la Chantourne, 38706 La Tronche Cedex, France; Thoracic Oncology Unit, Teaching Hospital A Michallon, BP217, 38043 Grenoble Cedex 9, France.
Brambilla E; Université Grenoble 1, INSERM, U 823, Institut A Bonniot, Université J Fourier, Rond-point de la Chantourne, 38706 La Tronche Cedex, France; Department of Pathology, Teaching Hospital A Michallon, BP217, 38043 Grenoble Cedex 9, France.

Lung Cancer ; 83(2): 182-8, 2014 Feb.

Article en En | MEDLINE | ID: mdl-24388706

Asunto(s)

Biomarcadores Farmacológicos; Carcinoma de Pulmón de Células no Pequeñas/diagnóstico; Resistencia a Antineoplásicos/genética; Neoplasias Pulmonares/diagnóstico; Tubulina (Proteína)/metabolismo; Proteína BRCA1/metabolismo; Biomarcadores de Tumor/metabolismo; Carcinoma de Pulmón de Células no Pequeñas/mortalidad; Carcinoma de Pulmón de Células no Pequeñas/patología; Inhibidor p27 de las Quinasas Dependientes de la Ciclina/metabolismo; Proteína Ligando Fas/metabolismo; Humanos; Inmunohistoquímica; Neoplasias Pulmonares/mortalidad; Neoplasias Pulmonares/patología; Metástasis de la Neoplasia; Estadificación de Neoplasias; Valor Predictivo de las Pruebas; Pronóstico; Estudios Prospectivos; Análisis de Supervivencia; Proteína p53 Supresora de Tumor/metabolismo; Proteína X Asociada a bcl-2/metabolismo; Receptor fas/metabolismo

Palabras clave

BRCA1; CI; DCR; DNA; Disease control rate; Drug response biomarkers; ERCC1; Fas ligand; FasL; HES; IHC; IQR; Immunohistochemistry; Lung neoplasms; MIA; NER; NSCLC; OS; PFS; PS; Prognosis; Survival; TUBB3; breast cancer susceptibility gene 1; class III ß-tubulin; confidence interval; deoxyribonucleic acid; disease control rate; enzyme repair cross-complementation group 1; hematoxylineosinsaffron; immunohistochemistry; interquartile range; microtubule-interfering agents; non-small cell lung cancer; nucleotide excision repair; overall survival; performance status; progression-free survival

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Carcinoma de Pulmón de Células no Pequeñas / Resistencia a Antineoplásicos / Biomarcadores Farmacológicos / Neoplasias Pulmonares Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2014 Tipo del documento: Article Pais de publicación: Irlanda

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