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Cellular uptake, cytotoxicity, apoptosis and DNA-binding investigations of Ru(II) complexes.
Shobha Devi, C; Nagababu, Penumaka; Natarajan, Sumathi; Deepika, N; Venkat Reddy, P; Veerababu, N; Singh, Surya S; Satyanarayana, S.
Afiliación
  • Shobha Devi C; Department of Chemistry, Osmania University, Hyderabad 500007, Andhra Pradesh, India.
  • Nagababu P; Department of Chemistry, Osmania University, Hyderabad 500007, Andhra Pradesh, India.
  • Natarajan S; Department of Biochemistry, Osmania University, Hyderabad 500007, India.
  • Deepika N; Department of Chemistry, Osmania University, Hyderabad 500007, Andhra Pradesh, India.
  • Venkat Reddy P; Department of Chemistry, Osmania University, Hyderabad 500007, Andhra Pradesh, India.
  • Veerababu N; Department of Biochemistry, Osmania University, Hyderabad 500007, India.
  • Singh SS; Department of Biochemistry, Osmania University, Hyderabad 500007, India.
  • Satyanarayana S; Department of Chemistry, Osmania University, Hyderabad 500007, Andhra Pradesh, India. Electronic address: ssnsirasani@gmail.com.
Eur J Med Chem ; 72: 160-9, 2014 Jan 24.
Article en En | MEDLINE | ID: mdl-24418931
ABSTRACT
Three new compounds, [Ru(Hdpa)2PyIP](ClO4)2·2H2O (1) [Ru(Hdpa)2FyIP](ClO4)2·2H2O (2) and [Ru(Hdpa)2IIP](ClO4)2·2H2O (3) have been synthesized and characterized by spectroscopic techniques such as elemental analysis, UV/Vis, FT-IR, (1)H NMR, (13)C NMR and mass spectra. The CT-DNA binding properties of 1-3 have been investigated by absorption, emission spectroscopy and viscosity measurements. Experimental results suggested that they can interact with DNA through intercalative mode with different binding strengths. These were found to promote the cleavage of plasmid DNA. Cell viability results indicated that all compounds showed significant dose dependent cytotoxicity in selected cell lines and 1 shown higher cytotoxicity than cisplatin on HeLa cells. Cellular uptake studies were studied by flow cytometry and confocal microscopy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Rubidio / ADN / Apoptosis / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2014 Tipo del documento: Article País de afiliación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Rubidio / ADN / Apoptosis / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2014 Tipo del documento: Article País de afiliación: India