Methyl palmitate attenuates lipopolysaccharide-induced acute lung injury in mice.
Clin Ter
; 164(6): e453-9, 2013.
Article
en En
| MEDLINE
| ID: mdl-24424222
ABSTRACT
AIM:
The study is aimed to determine the beneficial effects of methyl palmitate (MP) which has antioxidant and anti-inflammatory effects demonstrated on murine model of acute lung injury induced by lipopolysaccharide (LPS). MATERIALS ANDMETHODS:
Forty male BALB/C mice were randomly allocated into four groups (n=10, each) control group, methyl palmitate group (300 mg/kg), LPS group, and methyl palmitate -treated groups. Methyl palmitate or vehicle was given with an intraperitoneal administration 1 h before an intratracheal instillation of LPS (5 mg/kg). The severity of pulmonary injury was evaluated 6 h after LPS challenge. All experimental procedures complied with the requirements of the Animal Care and Ethics Committee of the Adnan Menderes University.RESULTS:
Methyl palmitate pretreatment significantly attenuated LPS-induced pulmonary histopathologic changes, alveolar hemorrhage, and neutrophil infiltration. Methyl palmitate pretreatment also reduced the concentrations of malondialdehyde in lung tissues.CONCLUSIONS:
This study indicates that methyl palmitate may have a protective effect against LPS-induced acute lung injury, and the potential mechanism of this action may involve the inhibition of NF-κB. activation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Palmitatos
/
Lesión Pulmonar Aguda
Tipo de estudio:
Prognostic_studies
Aspecto:
Ethics
Límite:
Animals
Idioma:
En
Revista:
Clin Ter
Año:
2013
Tipo del documento:
Article
País de afiliación:
Turquía