Nucleotide-sensitive ion channels in human insulin producing tumour cells.
Pflugers Arch
; 410(1-2): 169-72, 1987 Sep.
Article
en En
| MEDLINE
| ID: mdl-2446246
Cells from a human insulin producing tumour have been studied and single channel currents recorded. We have observed three main cation-selective channels in excised patch experiments. An ATP-sensitive potassium channel is present the activity of which can be inhibited by the oral hypoglycaemic drug, tolbutamide. A calcium-activated non-selective cation channel, which is inhibited by AMP could also be seen. In addition a large conductance potassium selective channel, possibly the "maxi" calcium-activated potassium channel is present in these cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Adenoma
/
Insulina
/
Canales Iónicos
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Pflugers Arch
Año:
1987
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Alemania