Induction of a stringent metabolic response in intracellular stages of Leishmania mexicana leads to increased dependence on mitochondrial metabolism.

Saunders, Eleanor C; Ng, William W; Kloehn, Joachim; Chambers, Jennifer M; Ng, Milica; McConville, Malcolm J

Saunders, Eleanor C; Ng, William W; Kloehn, Joachim; Chambers, Jennifer M; Ng, Milica; McConville, Malcolm J.

Afiliación

Saunders EC; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.
Ng WW; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.
Kloehn J; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.
Chambers JM; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.
Ng M; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.
McConville MJ; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.

PLoS Pathog ; 10(1): e1003888, 2014 Jan.

Article en En | MEDLINE | ID: mdl-24465208

Asunto(s)

Aminoácidos/metabolismo; Ciclo del Ácido Cítrico/fisiología; Glucosa/metabolismo; Leishmania mexicana/metabolismo; Leishmaniasis Cutánea/metabolismo; Mitocondrias/metabolismo; Aminoácidos/genética; Animales; Femenino; Glucosa/genética; Leishmania mexicana/genética; Leishmaniasis Cutánea/genética; Macrófagos/metabolismo; Macrófagos/parasitología; Macrófagos/patología; Ratones; Ratones Endogámicos BALB C; Mitocondrias/genética

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmania mexicana / Ciclo del Ácido Cítrico / Leishmaniasis Cutánea / Aminoácidos / Glucosa / Mitocondrias Límite: Animals País/Región como asunto: Mexico Idioma: En Revista: PLoS Pathog Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos

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