Withanolides from Physalis minima and their inhibitory effects on nitric oxide production.
Steroids
; 82: 38-43, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24480102
Six new withanolides (1-6), including two uncommon 1,10-seco withanolides (1 and 2), together with five known withanolides (7-11), were isolated from the whole plants of Physalis minima Linn.. The structures of new compounds were elucidated through spectroscopic methods, including (1)H, (13)C NMR, 2D-NMR, HRESIMS and circular dichroism (CD). Inhibitory effects of the isolates on nitric oxide (NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated. Compounds 2 and 5 showed strong inhibitory activities with IC50 values of 8.04 and 10.01 µM, respectively. Compounds 1, 9 and 10 exhibited moderate inhibitory activities with IC50 values from 25.54 to 43.58 µM.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Physalis
/
Witanólidos
/
Óxido Nítrico
Límite:
Animals
Idioma:
En
Revista:
Steroids
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Estados Unidos