Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target.

Azad, Gajendra Kumar; Singh, Vikash; Mandal, Papita; Singh, Prabhat; Golla, Upendarrao; Baranwal, Shivani; Chauhan, Sakshi; Tomar, Raghuvir S

Azad, Gajendra Kumar; Singh, Vikash; Mandal, Papita; Singh, Prabhat; Golla, Upendarrao; Baranwal, Shivani; Chauhan, Sakshi; Tomar, Raghuvir S.

Afiliación

Azad GK; Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462023, India.
Singh V; Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462023, India.
Mandal P; Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462023, India.
Singh P; Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462023, India.
Golla U; Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462023, India.
Baranwal S; Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462023, India.
Chauhan S; Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462023, India.
Tomar RS; Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal 462023, India.

FEBS Open Bio ; 4: 77-89, 2014.

Article en En | MEDLINE | ID: mdl-24490132

Palabras clave

CypA, Cyclophilin A; DCFH-DA, 2,7-dichlorodihydrofluorescein diacetate; Ebselen; FACS, florescence activated cell sorting; GDH, glutamate dehydrogenase; GSH, glutathione; Glutamate dehydrogenase; Histone clipping; Mitochondrial membrane potential; NAC, N-acetyl-l-cysteine; Ni-NTA, nickel-nitrilotriacetic acid; ROS levels; ROS, reactive oxygen species; SOD, superoxide dismutase; Yeast sporulation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: FEBS Open Bio Año: 2014 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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