Evaluation of neuroprotective effect of glucagon-like peptide 1 analogs using neuroimaging.
Alzheimers Dement
; 10(1 Suppl): S55-61, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24529526
ABSTRACT
There is increasing evidence to suggest that glucagon-like peptide 1 (GLP1) analogs are neuroprotective in animal models. In transgenic mice, both insulin and GLP1 analogs reduced inflammation, increased stem cell proliferation, reduced apoptosis, and increased dendritic growth. Furthermore, insulin desensitization was also observed in these animals, and reduced glucose uptake in the brain, as shown on FDG-PET imaging. In this review we discussed the role of PET and MRI in evaluating the effect of GLP1 analogs in disease progression in both Alzheimer's and Parkinson's disease. We have also discussed the potential novel PET markers that will allow us to understand the mechanism by which GLP1 exerts its effects.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fármacos Neuroprotectores
/
Enfermedades Neurodegenerativas
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Péptido 1 Similar al Glucagón
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Neuroimagen
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Alzheimers Dement
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido