Ergotism in Thailand caused by increased access to antiretroviral drugs: a global warning.
Top Antivir Med
; 21(5): 165-8, 2014 Jan.
Article
en En
| MEDLINE
| ID: mdl-24531557
ABSTRACT
Ergotism is a toxic condition resulting from overexposure to the ergot compounds produced by various fungi of the genus Claviceps. Traditionally, such exposure was due to ingestion of infected grains, but long-term or excessive use of medications containing ergot derivatives or drug-drug interactions between these medications can result in ergotism. Ergotamine, typically used to treat migraine, has less than 5% bioavailability due to extensive first-pass metabolism by cytochrome P450 3A4 (CYP3A4). Concurrent intake of ergotamine and strong CYP3A4 inhibitors, such as the HIV protease inhibitors (PIs), can lead to clinical ergotism. A total of 13 cases of clinical ergotism in HIV-infected patients has been published since 1997 (most recently reviewed by Frohlich et al).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Ergotismo
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Inhibidores de la Proteasa del VIH
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Antirretrovirales
/
Interacciones Farmacológicas
/
Ergotamina
Límite:
Adult
/
Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Top Antivir Med
Año:
2014
Tipo del documento:
Article
País de afiliación:
Tailandia