Multigene families of immunoglobulin domain-containing innate immune receptors in zebrafish: deciphering the differences.
Dev Comp Immunol
; 46(1): 24-34, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-24548770
ABSTRACT
Five large multigene families encoding innate-type immune receptors that are comprised of immunoglobulin domains have been identified in bony fish, of which four do not possess definable mammalian orthologs. The members of some of the multigene families exhibit unusually extensive patterns of divergence and the individual family members demonstrate marked variation in interspecific comparisons. As a group, the gene families reveal striking differences in domain type and content, mechanisms of intracellular signaling, basic structural features, haplotype and allelic variation and ligand binding. The potential functional roles of these innate immune receptors, their relationships to immune genes in higher vertebrate species and the basis for their adaptive evolution are of broad interest. Ongoing investigations are expected to provide new insight into alternative mechanisms of immunity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pez Cebra
/
Receptores Inmunológicos
/
Proteínas de Pez Cebra
Límite:
Animals
Idioma:
En
Revista:
Dev Comp Immunol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos