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Assessment of unconstrained cerebrovascular reactivity marker for large age-range FMRI studies.
Kannurpatti, Sridhar S; Motes, Michael A; Biswal, Bharat B; Rypma, Bart.
Afiliación
  • Kannurpatti SS; Department of Radiology, RUTGERS-New Jersey Medical School, Newark, New Jersey, United States of America.
  • Motes MA; School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas, United States of America.
  • Biswal BB; Department of Radiology, RUTGERS-New Jersey Medical School, Newark, New Jersey, United States of America ; Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, United States of America.
  • Rypma B; School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas, United States of America.
PLoS One ; 9(2): e88751, 2014.
Article en En | MEDLINE | ID: mdl-24551151
Breath hold (BH), a commonly used task to measure cerebrovascular reactivity (CVR) in fMRI studies varies in outcome among individuals due to subject-physiology and/or BH-inspiration/expiration differences (i.e., performance). In prior age-related fMRI studies, smaller task-related BOLD response variability is observed among younger than older individuals. Also, a linear CVR versus task relationship exists in younger individuals which maybe useful to test the accuracy of CVR responses in older groups. Hence we hypothesized that subject-related physiological and/or BH differences, if present, may compromise CVR versus task linearity in older individuals. To test the hypothesis, empirical BH versus task relationships from motor and cognitive areas were obtained in younger (mean age = 26 years) and older (mean age = 58 years) human subjects. BH versus task linearity was observed only in the younger group, confirming our hypothesis. Further analysis indicated BH responses and its variability to be similar in both younger and older groups, suggesting that BH may not accurately represent CVR in a large age range. Using the resting state fluctuation of amplitude (RSFA) as an unconstrained alternative to BH, subject-wise correspondence between BH and RSFA was tested. Correlation between BH versus RSFA was significant within the motor but was not significant in the cognitive areas in the younger and was completely disrupted in both areas in the older subjects indicating that BH responses are constrained by subject-related physiology and/or performance-related differences. Contrasting BH to task, RSFA-task relationships were independent of age accompanied by age-related increases in CVR variability as measured by RSFA, not observed with BH. Together the results obtained indicate that RSFA accurately represents CVR in any age range avoiding multiple and yet unknown physiologic and task-related pitfalls of BH.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Circulación Cerebrovascular / Contencion de la Respiración Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Circulación Cerebrovascular / Contencion de la Respiración Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos