Synapses need coordination to learn motor skills.

ABSTRACT

Experience-dependent remodeling of synaptic structure and function underlies information storage in the mammalian central nervous system. Although accumulating evidence suggests synergistic roles of long-term depression (LTD) and long-term potentiation (LTP) in cerebellar motor learning, their structural correlates and operational mechanisms have not been clearly addressed. A recent three-dimensional electron microscopic study provides insight for a potential complementary interplay between LTP and LTD in local dendritic segments of Purkinje cells of motor skill-trained animals. Complex motor skill training induced strengthening of a subset of parallel fiber synapses onto Purkinje cells by forming multiple-synapse boutons (MSBs) contacting spine pairs arising from the same dendrite, whereas MSB-neighboring synapses were weakened by reducing the size of the postsynaptic density. Here, we discuss these orchestrated structural modifications of neighboring synapses that may sharpen synaptic weight contrast in local dendritic segments, leading to enhanced signal-to-noise ratio for optimal motor skill retention.