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Reproductive toxicity in rats with crystal nephropathy following high doses of oral melamine or cyanuric acid.
Stine, Cynthia B; Reimschuessel, Renate; Keltner, Zachary; Nochetto, Cristina B; Black, Thomas; Olejnik, Nicholas; Scott, Michael; Bandele, Omari; Nemser, Sarah M; Tkachenko, Andriy; Evans, Eric R; Crosby, Tina C; Ceric, Olgica; Ferguson, Martine; Yakes, Betsy J; Sprando, Robert.
Afiliación
  • Stine CB; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: cynthia.stine@fda.hhs.gov.
  • Reimschuessel R; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: renate.reimschuessel@fda.hhs.gov.
  • Keltner Z; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: zachary.keltner@fda.hhs.gov.
  • Nochetto CB; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: cristina.nochetto@fda.hhs.gov.
  • Black T; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: thomas.black@fda.hhs.gov.
  • Olejnik N; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: nicholas.olejnik@fda.hhs.gov.
  • Scott M; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: michael.scott@fda.hhs.gov.
  • Bandele O; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: omari.bandele@fda.hhs.gov.
  • Nemser SM; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: sarah.nemser@fda.hhs.gov.
  • Tkachenko A; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: andriy.tkachenko@fda.hhs.gov.
  • Evans ER; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: eric.evans@fda.hhs.gov.
  • Crosby TC; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: tina.crosby@fda.hhs.gov.
  • Ceric O; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: olgica.ceric@fda.hhs.gov.
  • Ferguson M; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: martine.ferguson@fda.hhs.gov.
  • Yakes BJ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Electronic address: betsy.yakes@fda.hhs.gov.
  • Sprando R; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: robert.sprando@fda.hhs.gov.
Food Chem Toxicol ; 68: 142-53, 2014 Jun.
Article en En | MEDLINE | ID: mdl-24582682
ABSTRACT
The industrial chemical melamine was used in 2007 and 2008 to raise the apparent protein content in pet feed and watered down milk, respectively. Because humans may be exposed to melamine via several different routes into the human diet as well as deliberate contamination, this study was designed to characterize the effect of high dose melamine or cyanuric acid oral exposure on the pregnant animal and developing fetus, including placental transfer. Clear rectangular crystals formed following a single triazine exposure which is a different morphology from the golden spherulites caused by combined exposure or the calculi formed when melamine combines with endogenous uric acid. Crystal nephropathy, regardless of cause, induces renal failure which in turn has reproductive sequelae. Specifically, melamine alone-treated dams had increased numbers of early and late fetal deaths compared to controls or cyanuric acid-treated dams. As melamine was found in the amniotic fluid, this study confirms transfer of melamine from mammalian mother to fetus and our study provides evidence that cyanuric acid also appears in the amniotic fluid if mothers are exposed to high doses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Triazinas / Exposición Materna / Insuficiencia Renal Límite: Animals Idioma: En Revista: Food Chem Toxicol Año: 2014 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Triazinas / Exposición Materna / Insuficiencia Renal Límite: Animals Idioma: En Revista: Food Chem Toxicol Año: 2014 Tipo del documento: Article