Genetic background influences nicotine-induced conditioned place preference and place aversion in mice.
J Nippon Med Sch
; 81(1): 53-6, 2014.
Article
en En
| MEDLINE
| ID: mdl-24614397
ABSTRACT
This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced by genetic background.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ratones Endogámicos
/
Nicotina
Límite:
Animals
Idioma:
En
Revista:
J Nippon Med Sch
Asunto de la revista:
MEDICINA
Año:
2014
Tipo del documento:
Article