Thrombospondin-1 polymorphisms influence risk of corneal allograft rejection.
Invest Ophthalmol Vis Sci
; 55(4): 2115-20, 2014 Apr 07.
Article
en En
| MEDLINE
| ID: mdl-24618326
ABSTRACT
PURPOSE:
We investigated single nucleotide polymorphisms (SNPs) of thrombospondin-1 (TSP-1) on the risk of corneal allograft rejection. The TSP-1 is known to be involved in the immune response of the anterior chamber of the eye, activating TGF-ß2, promoting peripheral and systemic tolerance, and counteracting the proangiogenic activity of VEGF.METHODS:
Three tagging SNPs spanning the TSP-1 region (rs1478604, A>G; rs2228261, C>T; and rs2228262, A>G) were genotyped. Association with risk of rejection was investigated in a group of 378 corneal transplant recipients with risk factors for allograft rejection. Transplant recipients had completed 3-year follow-up.RESULTS:
The TSP-1 rs1478604 A SNP was associated significantly with an increased risk of corneal allograft rejection (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.02-2.45; P = 0.04) and there was a trend toward the rs1478604, rs2228261, rs2228262 ACA haplotype increasing risk of rejection.CONCLUSIONS:
The results suggest that TSP-1 rs1478604 AA homozygotes may be at increased risk of corneal transplant rejection, especially if they carry the ACA haplotype.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
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ADN
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Trasplante de Córnea
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Trombospondina 1
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Predisposición Genética a la Enfermedad
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Rechazo de Injerto
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Supervivencia de Injerto
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido