Dose-response effect of a novel functional fibre, PolyGlycopleX(®), PGX(®), on satiety.
Appetite
; 77: 72-6, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24631638
ABSTRACT
The objective of this research was to determine the dose-response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX(®) (PGX(®)), [(α-D-glucurono-α-manno-ß-D-manno-ß-D-gluco), (α-Lgulurono-ß-D mannurono), (ß-D-gluco-ß-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n = 10), aged between 20.3 and 29.2 years, consumed PGX(®), in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX(®) doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7, P = 0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polisacáridos Bacterianos
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Saciedad
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Glucemia
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Fibras de la Dieta
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Alginatos
Tipo de estudio:
Clinical_trials
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Prognostic_studies
Límite:
Adult
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Humans
Idioma:
En
Revista:
Appetite
Año:
2014
Tipo del documento:
Article